The latest

Binding of Copper and Cisplatin to Atox1 is Mediated by Glutathione through the Formation of Metal-Sulfur Clusters.

Dolgova, N.V., Yu. C., Cvitkovic, J.P., Hodak, M., Nienaber, K., Summers, K.L., Cotelesage, J., Bernholc, J., Kaminski, G.A., Pickering, I.J., George, G.N., and  Dmitriev, O.Y. (2017), Biochemistry,  56: 3129–3141

Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A.

Yu, C.H., Dolgova, N.V., and Dmitriev, O.Y.  (2017) IUBMB Life, 69: 226-235

Nanobodies as Probes for Protein Dynamics in Vitro and in Cells

Dmitriev, O.Y., Lutsenko, S., and Muyldermans,  S. (2016) J. Biol. Chem., 291: 3767-3775

Interactions Between Metal-Binding Domains Modulate Intracellular Targeting of Cu(I)-ATPase ATP7B, as Revealed by Nanobody Binding

Huang, Y., Nokhrin, S., Hassanzadeh-Ghassabeh, G., Yu, C., Yang,H., Barry, A.N.,  Tonelli, M.. Markley, J.L., Muyldermans,  S., Dmitriev, O.Y., Lutsenko, S. (2014) J. Biol. Chem., 289:32682-93

The use of nanopore analysis for discovering drugs which bind to α-synuclein for treatment of Parkinson's disease

Tavassoly, O., Kakish, J., Nokhrin, S., Dmitriev, O.Y. and Lee, J.S. (2014) Eur. J. Med. Chem. 88:42-54

Cu(II) and dopamine bind to α-synuclein and cause large conformational changes.

Tavassoly, O., Nokhrin, S., Dmitriev, O.Y. and Lee, J.S. (2014) FEBS J., 281(12):2738-53

Copper chaperone Atox1 interacts with the metal-binding domain of Wilson disease protein in cisplatin detoxification.

Dolgova, N.V., Nokhrin, S., Yu, C., George, G.N., and Dmitriev, O.Y. (2013) Biochem. J. 454:147-56

One-Step Amino Acid Selective Isotope Labeling of Proteins in Prototrophic E. coli Strains,

O’Grady, C., Rempel, B.L., Sokaribo, A. and Dmitriev, O.Y. (2012) Anal. Biochem. 426, 126-128

Molecular Events Initiating Exit of a Copper-Transporting ATPase ATP7B from the Trans-Golgi Network

Hasan, N.M., Gupta, A., Polishchuk, E.,  Yu, C.H., Polishchuk, Dmitriev, O.Y.  and Lutsenko, S. (2012)  J. Biol.Chem. 287, 36041–36050

Cell-free synthesis of membrane subunits of ATP synthase in phospholipid bicelles: NMR shows subunit a fold similar to the protein in the cell membrane.

Uhlemann, E.E., Pierson, H.E, Fillingame, R.H. and Dmitriev, O.Y.  Protein Sci. 21, 279-288

Interaction With Monomeric Subunit c Drives Insertion of ATP Synthase Subunit a into the Membrane and Primes a-c Complex Formation.

Pierson, H.E., Uhlemann, E.E. and Dmitriev, O.Y. (2011) J. Biol.Chem. 286, 38583-38591

Difference in Stability of the N-Domain Underlies Distinct Intracellular Properties of the E1064A and H1069Q Mutants of Cu-transporting ATPase ATP7B.

Dmitriev, O.Y., Bhattacharjee, A., Nokhrin, S., Uhlemann, E.E., and Lutsenko, S. (2011) J. Biol.Chem. 286, 16355-16362

Disease Mutation or Polymorphism? Cellular Copper Levels Determine the Phenotype of the Arg875 Variant of ATP7B/Wilson Disease

Gupta, A., Bhattacharjee, A., Dmitriev, O., Nokhrin, S., Braiterman, L., Hubbard, A., Lutsenko, S. (2011) Proc.Natl.Acad.Sci. USA, 108, 5390-5395

Mechanism Of Tumor Resistance To Cisplatin Mediated by the Copper Transporter ATP7B

Dmitriev, O.Y. (2011) Biochem. Cell Biol. 89, 138-147

Crystallization and Preliminary X-ray studies of the N-domain of the Wilson Disease Associated Protein

Liu, L., O'Grady,  C., Dalrymple, S.A., Prasad, L.,  Dmitriev, O. Y., and Delbaere, L.T. (2009) Acta Crystallographica F 65:621-624

The soluble metal-binding domain of copper transporter ATP7B binds and detoxifies cisplatin.

Dolgova, N.V., Olson, D., Lutsenko, S., and Dmitriev, O. Y.  (2009) Biochem. J, 419, 51-56

Interaction of Transmembrane Helices in ATP Synthase Subunit a in Solution as Revealed by Spin-Label Difference NMR

Dmitriev, O. Y., Freedman, K. H., Hermolin, J. and Fillingame, R.H. (2008) Biochim. Biophys. Acta (Bioenergetics), 1777: 227-237

Function and Regulation of Human Copper-Transporting ATPases

Lutsenko, S., Barnes, N.L., Bartee, M.Y., Dmitriev, O.Y. (2007) Physiol. Revs., 87: 1011-1046

The Rigid Connecting Loop Stabilizes Hairpin Folding of the Two Helices of the ATP Synthase Subunit c.

Dmitriev, O. and Fillingame, R.H. (2007)  Protein Science 16: 2118-2122

Solution Structure of the N-domain of Wilson Disease Protein: Unique Nucleotide-Binding Environment and Effects of Disease Mutations

Dmitriev, O., Tsivkovskii, R., Abildgaard, F., Morgan, C.T.,  Markley, J.L. and   Lutsenko, S. (2006) Proc. Natl. Acad. Sci. USA 103: 5302-5307

NMR assignment of the Wilson Disease Associated Protein N-Domain

Dmitriev, O., Tsivkovskii, R., Abildgaard, F., and   Lutsenko, S. (2006) J. Biomol. NMR, 36,  Suppl. 1:61