"CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis”. PMID: 24126059.
This work is the first to demonstrate a key role for the recently identified stress response protein, CREB3L1, in cancer. We show that CREB3L1 is lost during the progression from low grade to high grade breast cancer. The loss of CREB3L1 expression alters the gene expression profile of a number of pro-cancer genes, enabling the cells to develop a more aggressive phenotype and metastasize. These data suggest that loss of CREB3L1 expression is a requisite step for breast cancer growth, survival and metastasis, and may be a useful marker in predicting tumor grade and patient prognosis. These are novel findings which significantly contribute to our understanding of how the stress response protein CREB3L1 functions in cancer.