Genomic ASSETS for Livestock

The Genomic ASSETS (Antimicrobial Stewardship Systems from Evidence-Based Treatment Strategies) for Livestock research team is developing genomic tools and strategies to rapidly field-test groups of calves for disease and antibiotic resistance

Research Vision

To combat the global challenge of antimicrobial resistance and need for antimicrobial stewardship:

  • Timely diagnostic test results must confirm when antimicrobials are needed to manage disease.
  • If antimicrobial use is required, evidence-based diagnostic strategies should guide prudent drug selection.
  • Low-risk groups of calves less likely to need antimicrobials for disease control should be identified.
  • Identification of bacteria and viruses can help pinpoint vaccine gaps.

Our Research Goals

  • Diagnostic workflows using cutting-edge, commercially available genomic platforms. We will apply Oxford Nanopore Technologies sequencing methods and explore other emerging tools such as recombinase polymerase amplification.
  • Animal sampling and testing strategies (collection methods, timing, required sample numbers) for practicality, compatibility with feedlot practices and utility of resulting information.
  • Dynamic risk assessment tools to support prudent antimicrobial selection for treatment and disease control (pen-level precision medicine) using agent-based models supplemented with economic data.

 

Project Manager: lianne.mcleod@usask.ca