Publications
Recent Publications
2025:
Barnard, I. L., McElroy, D. L., Young, K. M., Terstege, D. J., Glass, A. E., Epp, J. R., ... & Howland, J. G. (2025). Activity of CaMKII-expressing neurons in medial prefrontal cortex of male and female Long-Evans rats is necessary for encoding odor information and novelty recognition in an odor-based incidental memory test. Cerebral Cortex, 35(8). https://doi.org/10.1093/cercor/bhaf203
McElroy, D. L., Barnard, I. L., Glass, A. E., Young, K. M., Kryachko, V., Botterill, J. J., & Howland, J. G. (2025). DREADD-mediated inhibition of anterior retrosplenial cortex: Effects on novelty recognition of objects, locations, and object-in-place associations in male and female Long Evans rats. Neurobiology of Learning and Memory. https://doi.org/10.1016/j.nlm.2025.108055
Black, T., Barnard, I. L., Baccetto, S. L., Greba, Q., Orvold, S. N., Austin-Scott, F. V., ... & Howland, J. G. (2025). Differential effects of gestational Cannabis smoke and phytocannabinoid injections on male and female rat offspring behavior. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 136. https://doi.org/10.1016/j.pnpbp.2024.111241
The Howland Lab was featured on the cover of Learning & Memory (June, 2017)
2024
Black, T., Jenkins, B. W., Laprairie, R. B., & Howland, J. G. (2024). Therapeutic potential of gamma entrainment using sensory stimulation for cognitive symptoms associated with schizophrenia. Neuroscience and biobehavioral reviews, 161. https://doi.org/10.1016/j.neubiorev.2024.105681
Onofrychuk, T. J., Heidt, A. L., Orvold, S. N., Greba, Q., & Howland, J. G. (2024). Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats. Psychopharmacology, 241(5), 963-974. https://doi.org/10.1007/s00213-023-06522-4
Onofrychuk, T. J., Glass, A. E., Greba, Q., & Howland, J. G. (2024). Evidence for novelty reward cross-cueing in the odor span task in rats: implications for odor-based reward-motivated tasks. Learning & Memory, 31(1-2), https://doi.org/10.1101/lm.053871.123
2023
Barnard, I. L., Onofrychuk, T. J., Toderash, A. D., Patel, V. N., Glass, A. E., Adrian, J. C., Laprairie, R.B., & Howland, J. G. (2023). High-THC Cannabis smoke impairs working memory capacity in spontaneous tests of novelty preference for objects and odors in rats. bioRxiv, 2023-04. https://doi.org/10.1523/ENEURO.0115-23.2023
Sandini, T. M., Onofrychuk, T. J., Roebuck, A. J., Hammond, S. A., Udenze, D., Hayat, S., Herdzik, M.A., McElroy, D.L., Orvold, S.N., Greba, Q., Laprairie, R.B.,& Howland, J. G. (2023). Repeated exposure to high-THC Cannabis smoke during gestation alters sex ratio, behavior, and amygdala gene expression of Sprague Dawley rat offspring. eneuro, 10(11). https://doi.org/10.1523/ENEURO.0100-23.2023
Harman, T., Udoh, M., McElroy, D. L., Anderson, L. L., Kevin, R. C., Banister, S. D., Ametovski, A., Markham, J., Bladen, C., Doohan, P. T., Greba, Q., Laprairie, R. B., Snutch, T. P., McGregor, I. S., Howland, J. G., & Arnold, J. C. (2023). MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy. Front Physiol, 14, 1086243. https://doi.org/10.3389/fphys.2023.1086243
Park, A., Jacob, A. D., Hsiang, H. L., Frankland, P. W., Howland, J. G., & Josselyn, S. A. (2023). Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice. Neuropsychopharmacology, 48(5), 724-733. https://doi.org/10.1038/s41386-022-01472-5
2022
Jansen, E. B., Orvold, S. N., Swan, C. L., Yourkowski, A., Thivierge, B. M., Francis, M. E., Ge, A., Rioux, M., Darbellay, J., Howland, J. G., & Kelvin, A. A. (2022). After the virus has cleared-Can preclinical models be employed for Long COVID research? PLoS Pathog, 18(9), e1010741. https://doi.org/10.1371/journal.ppat.1010741
Cromar, G. L., Epp, J. R., Popovic, A., Gu, Y., Ha, V., Walters, B. J., St Pierre, J., Xiong, X., Howland, J. G., Josselyn, S. A., Frankland, P. W., & Parkinson, J. (2022). Toxoplasma infection in male mice alters dopamine-sensitive behaviors and host gene expression patterns associated with neuropsychiatric disease. PLoS Negl Trop Dis, 16(7), e0010600. https://doi.org/10.1371/journal.pntd.0010600
Barnard, I. L., Onofrychuk, T. J., Sandini, T. M., McElroy, D. L., Zagzoog, A., Roebuck, A. J., Austin-Scott, F. V., Laprairie, R. B., & Howland, J. G. (2022). The effects of acute Cannabis smoke or Delta(9)-THC injections on the trial-unique, nonmatching-to-location and five-choice serial reaction time tasks in male Long-Evans rats. Neurobiol Learn Mem, 192, 107624. https://doi.org/10.1016/j.nlm.2022.107624
Howland, J. G., Ito, R., Lapish, C. C., & Villaruel, F. R. (2022). The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands. Neurosci Biobehav Rev, 135, 104569. https://doi.org/10.1016/j.neubiorev.2022.104569
McElroy, D. L., Roebuck, A. J., Greba, Q., Garai, S., Brandt, A. L., Yilmaz, O., Cain, S. M., Snutch, T. P., Thakur, G. A., Laprairie, R. B., & Howland, J. G. (2022). The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg. IBRO Neurosci Rep, 12, 121-130. https://doi.org/10.1016/j.ibneur.2022.01.006
Roebuck, A. J., Greba, Q., Onofrychuk, T. J., McElroy, D. L., Sandini, T. M., Zagzoog, A., Simone, J., Cain, S. M., Snutch, T. P., Laprairie, R. B., & Howland, J. G. (2022). Dissociable changes in spike and wave discharges following exposure to injected cannabinoids and smoked cannabis in Genetic Absence Epilepsy Rats from Strasbourg. Eur J Neurosci, 55(4), 1063-1078. https://doi.org/10.1111/ejn.15096
2021
Barnard, I. L., Onofrychuk, T. J., McElroy, D. L., & Howland, J. G. (2021). The Touchscreen-Based Trial-Unique, Nonmatching-To-Location (TUNL) Task as a Measure of Working Memory and Pattern Separation in Rats and Mice. Curr Protoc, 1(9), e238. https://doi.org/10.1002/cpz1.238
Scott, G. A., Terstege, D. J., Roebuck, A. J., Gorzo, K. A., Vu, A. P., Howland, J. G., & Epp, J. R. (2021). Adult neurogenesis mediates forgetting of multiple types of memory in the rat. Mol Brain, 14(1), 97. https://doi.org/10.1186/s13041-021-00808-4
Roebuck, A. J., Greba, Q., Smolyakova, A. M., Alaverdashvili, M., Marks, W. N., Garai, S., Baglot, S. L., Petrie, G., Cain, S. M., Snutch, T. P., Thakur, G. A., Hill, M. N., Howland, J. G., & Laprairie, R. B. (2021). Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg. Neuropharmacology, 190, 108553. https://doi.org/10.1016/j.neuropharm.2021.108553
Brymer, K. J., Kulhaway, E. Y., Howland, J. G., Caruncho, H. J., & Kalynchuk, L. E. (2021). Altered acoustic startle, prepulse facilitation, and object recognition memory produced by corticosterone withdrawal in male rats. Behav Brain Res, 408, 113291. https://doi.org/10.1016/j.bbr.2021.113291
McElroy, D. L., Roebuck, A. J., Scott, G. A., Greba, Q., Garai, S., Denovan-Wright, E. M., Thakur, G. A., Laprairie, R. B., & Howland, J. G. (2021). Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies. Psychopharmacology (Berl), 238(4), 1087-1098. https://doi.org/10.1007/s00213-020-05755-x
Onofrychuk, T. J., Cai, S., McElroy, D. L., Roebuck, A. J., Greba, Q., Garai, S., Thakur, G. A., Laprairie, R. B., & Howland, J. G. (2021). Effects of the cannabinoid receptor 1 positive allosteric modulator GAT211 and acute MK-801 on visual attention and impulsivity in rats assessed using the five-choice serial reaction time task. Prog Neuropsychopharmacol Biol Psychiatry, 109, 110235. https://doi.org/10.1016/j.pnpbp.2020.110235
2020
Sandini, T. M., Greba, Q., Lins, B. R., & Howland, J. G. (2020). Maternal Immune Activation with the Viral Mimetic Poly:IC in Pregnant Rats. Bio Protoc, 10(22), e3817. https://doi.org/10.21769/BioProtoc.3817