Principal Investigator

Adelaine Leung, PhD

Dr. Adelaine Leung is a faculty member at the Veterinary Biomedical Sciences at the Western College of Veterinary Medicine, University of Saskatchewan.

Dr. Leung graduated with a BSc and MSc from the Department of Biochemistry at McMaster University. She finished her Master’s thesis in the laboratory of Dr. Albert Berghuis where she determined the structures of an inhibitor-bound lytic transglycosylase and the apo form of the aminoglycoside phosphotransferase (APH), an enzyme that confers antibiotic resistance in bacteria. Afterwards, she worked for two years as a research associate in the laboratory of Dr. David Borhani at the Southern Research Institute in Birmingham, Alabama, USA, working on several structure-based drug design projects. Next, Dr. Leung joined the laboratory of Dr. Kiyoshi Nagai at the MRC-Laboratory of Molecular Biology, University of Cambridge, UK, where she determined the structure of the spliceosomal U4 snRNP core domain (an 8 subunit complex containing 7 proteins + 1 RNA) of her Ph.D. project. The core domain is a common structural architecture present in four of the five major spliceosomal snRNPs that participate in RNA splicing. The structure provides the first high-resolution description of the RNA-protein interactions at the heart of the core domain.  The structure also explains all the known biochemical observations and suggests the general mechanism of higher-level assemblies of snRNPs. After receiving training in structural biology, Dr. Leung became interested in the potential of teasing out molecular mechanisms underlying animal behaviours. Dr. Leung joined the laboratory of Dr. Edward Kravitz at the Department of Neurobiology, Harvard Medical School, where she investigated how neural circuits gave rise to innate behaviours by studying the fruitless circuit that is important for sexually dimorphic behaviours in Drosophila. Subsequently, Dr. Leung’s research interest expanded to understanding the molecular mechanisms of neuropsychiatric diseases. She became interested in the protein DISC1 and its protein-protein interaction network, which have been implicated in psychiatric diseases. Dr. Leung joined the Haggarty Lab (Mass General Hospital, Harvard Medical School), who previously established the role of DISC1 in the Wnt signaling pathway, and worked on the identification of chemical probes of DISC1 and GSK3b. Dr. Leung started her own laboratory in 2012 and has continued her research interest in unraveling the neurobiology of animal behaviours.

LAB MEMBERS

Narsimha Pujari
Narsimha Pujari | Ph.D. Candidate

Dipesh Shahi, Ph.D. Candidate
Dipesh Shahi | Ph.D. Student

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Yona Al-Tahir | M.Sc. Student

Kamea Chevrier | Research Technician | Accepted into SLP program, U of A

Aidin Shaikhei | Undergraduate Student

Hasnain Ali | Undergraduate Student

Doris Yim | Undergraduate Student


 

ALUMNI

Postdoctoral Fellows

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Shreyas Jois | Post doctorial fellow (2016-2020) | Current affiliation: Histology Suite Supervisor, University of Saskatchewan

Steve Gagné, Ph.D. (2014-2016)

Research Staff

Samat Amat

Samat Amat | Assistant Professor, Department of Microbiological Sciences, North Dakota State University (Website)

Student Researchers

Graduate Students

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Anand Krishnan | M.Sc. (2017-2020) | Current affiliation: Research Technician II, CancerCare, Manitoba

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Stephanie Saundh | M.Sc. (2016-2019) | Current affiliation: Research Technician, Rasmussen Lab, Vaccine and Infectious Disease Organization (VIDO)


U of S Undergraduate Students

Natalie Turriff
Natalie Turriff | Research Technician (2024-2025) | Current affiliation: accepted into the MD program, College of Medicine, University of Saskatchewan

Vanessa Browne
Vanessa Browne | Undergraduate thesis student (2022-2023) | Current affiliation: MD program, College of Medicine, University of Saskatchewan

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Edward Gardner | Undergraduate student (2018-2019) | Graduate Student, University of Ottawa

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Sean Lipsit | Undergraduate thesis student (2017-2018) | Current affiliation: Future Science Leaders Program Manager, Science World, Vancouver, BC.

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Robert Bigsby | Undergraduate thesis student (2016-2017) | Current affiliation: PostGraduate Medical Program, Cardiac Surgery, University of Ottawa


DVM Summer Students

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Bonnie Chu | DVM Summer Student (2017) | Current affiliation: Clinical Lab Animal Veterinarian, The Hospital for Sick Children, Toronto

Tammy Wong, DVM Summer Student (2013)


Mitacs Summer Students

Marity Dessolain
Marity Dessolain | Mitacs Summer student (2022) | Current affiliation: Forensic Identification Specialist, French National Police

Drushti Naik
Drushti Naik | Mitacs Summer student (2022) | Current affiliation: Market Research Analyst, GRG Health, India

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Khushi Doshi | Mitacs Student (Remote, 2020) | Current affiliation: Research Student, Shafiee lab, Harvard Medical School

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Molly Bullington | Mitacs Student (Remote, 2020)

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Avadhoot Jadhav | Mitacs Student (Remote, 2020)

Joline Janz | Mitacs Student (Remote, 2020)

Oliver Lindhorst | Mitacs Student (Remote, 2020)

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Vijayaditya Ray | Mitacs Summer Student (2019) | Current affiliation: Ph.D. Student, Ludwig-Maximilians-University of Munich

Tianyu Gao | Mitacs Summer Student (2019) | Current affiliation: Ph.D. Student, University of Illinois

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Ben Wieland | Mitacs Summer Student (2018) | Current affiliation: Graduate Student in Germany