DROSOPHILA BEHAVIOURAL GENETICS

Jois, S., Chan, Y.B., Fernandez, M.P., Pujari, N., Janz, L.J., Leung, A.K.* (2022) Sexually dimorphic cholinergic mechanosensory neurons regulate copulation duration and persistence. Scientific Reports. 12, 6177. (https://doi.org/10.1038/s41598-022-10247-3)

Jois, S., Chan, Y.B., Fernandez, M.P., Leung, A.K.* (2018) Characterization of the Sexually Dimorphic fruitless Neurons that Regulate Copulation Duration. Frontiers in Physiology. 9, 780.  (https://doi.org/10.3389/fphys.2018.00780)

Andrews, J.C., Fernández, M.P., Yu, Q., Leary, G.P., Leung, A.K., Kavanaugh, M.P., Kravitz, E.A., Certel, S.J. (2014) Octopamine neuromodulation regulates Gr32a-linked aggression and courtship pathways in Drosophila males.  PLOS Genetics 10, e1004356

Mundiyanapurath, S., Chan, Y.B., Leung, A.K., Kravitz, E.A. (2009) Feminizing cholinergic neurons in a male Drosophila nervous system enhances aggression. Fly 3(3), 179-84.

BIOCHEMISTRY AND STRUCTURAL BIOLOGY

Pujari, N., Saundh, S., Acquah, F.A., Mooers, B.H.M., Ferré-D’Amaré, A.R. & Leung, A.K.* (2021) Engineering crystal packing in RNA structures I: Past and future strategies for engineering RNA packing in crystals. Crystal 11(8), 952 (https://doi.org/10.3390/cryst11080952)

Leung, A.K.*, Li, J., Krummel, D., Kondo, Y., Roon, M., V. (2021) Engineering crystal packing in RNA-protein complexes II: A historical perspective from the structural studies of the spliceosome. Crystal 11(8), 948 (https://doi.org/10.3390/cryst11080948)

Saundh, S., Patnaik, D., Gagné, S., Bishop, J., Pujari, N., Nambisan, A.K., Aimait, S., Bigsby, R., Lipsit, S., Murphy, M., Tsai, L-H., Haggarty, S.*, Leung, A.K.* (2020) Identification and Mechanistic Characterization of a Novel Peptide Inhibitor of Glycogen Synthase Kinase (GSK3) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein. ACS Chem Neurosci. 11, 4128-4138.

Leung, A.K., Ramesh, N., Vogel, C., Unniappan, S.* (2019) Nucleobindins and Encoded Peptides: From Cell Signaling to Physiology. In Advances in Protein Chemistry and Structural Biology, Donev, R., Ed. Elsevier, Acaedmic Press: Vol. 116, p 91-133.

Li, J.*, Leung, A.K., Kondo, Y., Oubridge, C. and Nagai, K.* (2016) Re-refinement of the spliceosomal U4 snRNP core-domain structure. Acta Cryst. D72, 131-146. (Impact Factor: 7.652, Number of Citation: 13)

Leung, A.K., Nagai, K. and Li, J. (2011) Crystal Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.  Nature 473, 536-539.

Leung, A.K., Kambach, C., Kondon, Y., Kampmann, M., Jinek, M. and Nagai, K. (2010) Use of RNA Tertiary Interaction Modules for the Crystallisation of the Spliceosomal snRNP Core Domain. J. Mol. Biol 402, 154-164.

Oubridge, C., Krummel, D.A., Leung, A.K., Li, J., Nagai, K. (2009) Interpreting a low resolution map of human U1 snRNP using anomalous scatterers. Structure 17(7), 930-8.

Pomeranz Krummel, D.A., Oubridge, C., Leung, A.K., Li, J., Nagai K. (2009) Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution. Nature 458(7237), 475-80.

Reynolds, R.C., Campbell, S.R., Fairchild, R.G., Kisliuk, R.L., Micca, P.L., Queener, S.F., Riordan, J.M., Sedwick, W.D., Waud, W.R., Leung, A.K., Dixon, R.W., Suling, W.J., Borhani, D.W. (2007) Novel boron containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation. J. Med. Chem. 50, 3283-3289.

Leung, A.K. and Nagai, K. (2005) Gemin 6 and 7 lend a hand to snRNP assembly.  Structure, 13(6), 833-4.

Leung, A.K., White, LE., Ross, LJ, Reynolds, RC, DeVito, JA, Borhani, DW. (2004) Structure of Mycobacterium tuberculosis FtsZ Reveals Unexpected, G Protein-like Conformational Switches J Mol Biol., 342, 953-70.

Borhani, D.W., Calderwood, D.J., Friedman, M.M., Hirst, G.C., Li, B., Leung, A.K., McRae, B., Ratnofsky, S., Ritter, K. and Waegell, W. (2004)  A potent, orally active inhibitor of lck with efficacy in a model of transplant rejection Bioorganic & Medicinal Chemistry Letters, 14(10), 2613-2616.

Burk, D.L., Hon, W.-C., Leung, A.K., and Berghuis, A.M. (2001) Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase. Biochemistry, 40, 8756-64.

Leung, A.K., Duewel, H.S., Honek, J. F., and Berghuis, A.M. (2001) Crystal structure of the lytic transglycosylase from bacteriophage lambda in complexed with hexa-N-acetylchitohexaose. Biochemistry, 40, 5665 -5673.

Leung, A.K., White, E.L., Ross, L.J., and Borhani, D.W. (2000) Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ. Acta Cryst., D56, 1634-1637.

Leung, A.K., Park, M.M.V., and Borhani, D.W. (1999) An improved method for protein crystal density measurements. J. Appl. Cryst.,  32, 1006-1009.

 

Patent

US 7,400,979 B2 (15-JUL-2008) Borhani, David W.; Calderwood, David; Dixon, Richard W.; Hirst, Gavin C.; Hrnciar, Peter; Loew, Andreas; Leung, Adelaine; Ritter, Kurt. “Method of identifying inhibitors of Lck.” (Abbott Laboratories, Inc.). PCT Int. Appl. WO 2003/020880 A2 (Filed 2-AUG-2002, Publ. 13-MAR-2003); US Appl. US 2002 10/212,346 A (Filed 5-AUG-2002, Publ. 18-SEP-2003). Priority: U.S. Provisional Appl. No. 60/310,051 filed 3-AUG-2001.