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Cancer Research Cluster
Work in Dr. Lukong’s lab is centred on breast tumour kinase (BRK) and two other BRK family members, FRK and SRMS. BRK is overexpressed in the majority of breast carcinomas and tends to function as an oncogene, while FRK displays tumor suppressor activity in breast cancer. The cellular roles of SRMS are unknown. The Lukong lab is investigating the cellular and physiological roles, and the mechanisms of action and modes of regulation of all three kinases in breast cancer. The Lukong lab is also characterizing the diagnostic, prognostic and therapeutic potential of BRK and FRK in breast cancer. Google Scholar link