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Dr. Joseph P. Clarke's Latest Paper Accepted to Frontiers in Molecular Biosciences!
Congratulations to our post-doctoral fellow, Dr. Joseph P. Clarke, on the acceptance of his paper titled, "Sequence- and structure-specific RNA oligonucleotide binding attenuates heterogeneous nuclear ribonucleoprotein A1 dysfunction" to the journal Frontiers in Molecular Biosciences! In a cellular model that imitates aspects of MS, Dr. Clarke and colleagues demonstrated that RNA oligonucleotides attenuate heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) dysfunction and its detrimental downstream cellular effects. This is important because hnRNPA1 dysfunction has been shown to contribute to the pathogenesis of MS and using RNA oligonucleotides to disrupt hnRNPA1 dysfunction may be used as a treatment for MS.